Brain regions influenced by the lateral parabrachial nucleus in angiotensin II-induced water intake

Abstract

This study examined which brain regions are influenced by an inhibitory lateral parabrachial nucleus (LPBN) mechanism that affects water intake. Controls and rats with bilateral LPBN lesions were administered angiotensin II (AngII) (0.5. mg/kg subcutaneous - SC), drinking responses measured, and brains processed for Fos-immunohistochemistry. A separate group of LPBN-lesioned and non-lesioned animals were denied water for 90. min prior to perfusion to remove any confounding factor of water intake. LPBN-lesioned rats drank a cumulative volume of 9. mL compared with <4. mL by controls (p<. 0.01). Compared with sham-lesioned animals, Fos expression was attenuated in overdrinking LPBN-lesioned ra..